David Sinclair
Professor of Genetics, Harvard Medical School · Author, Lifespan
"Aging is an information problem — the body loses the epigenetic instructions that tell cells how to function. Sinclair's protocol targets NAD⁺ restoration, sirtuin activation, and mTOR suppression to slow the loss of that information and, in animal models, partially reverse it."
Peter Attia
Physician · Author, Outlive · Host, The Drive Podcast
"Attia frames longevity medicine as 'Medicine 3.0' — proactive, personalised, and focused on the four horsemen of chronic disease (cardiovascular disease, cancer, neurodegenerative disease, metabolic dysfunction). His protocol is anchored in exercise as the single most powerful longevity lever, with supplements playing a supporting role."
Rhonda Patrick
PhD Biomedical Science · Host, FoundMyFitness Podcast
"Patrick's framework centres on micronutrient sufficiency as the foundation of longevity — the idea that most people are deficient in key vitamins and minerals that act as cofactors in DNA repair and mitochondrial function. She layers targeted supplementation on top of an exercise-first, whole-food baseline."
Andrew Huberman
Professor of Neuroscience, Stanford School of Medicine · Host, Huberman Lab Podcast
"Huberman's framework is rooted in neuroscience and behavioural tools — light exposure, sleep, and stress management come first, with supplements playing a secondary, targeted role. He emphasises free, zero-cost protocols (morning sunlight, cold exposure, deliberate breathing) as the highest-leverage longevity tools."
Bryan Johnson
Entrepreneur · Founder, Blueprint Protocol
"Johnson's Blueprint protocol is the most data-intensive self-experiment in longevity history — 100+ biomarkers tracked monthly, a team of 30+ physicians, and a goal of achieving the biological age of an 18-year-old. His philosophy is 'don't die' and he treats his body as an algorithm to be optimised, not a lifestyle to be enjoyed."
Valter Longo
Professor of Gerontology, USC · Director, Longevity Institute · Author, The Longevity Diet
"Longo's research centres on the fasting-mimicking diet (FMD) and its ability to trigger cellular rejuvenation through autophagy and stem cell activation. He argues that periodic, not chronic, caloric restriction is the key to longevity — and that diet is the most powerful drug we have."
Morgan Levine
Principal Investigator, Altos Labs · Former Yale Professor · Author, True Age
"Levine developed PhenoAge and GrimAge — two of the most validated biological age clocks. Her work shows that biological age is modifiable and that lifestyle interventions can measurably reverse it. She advocates for measuring, not guessing, your rate of aging."
Eric Verdin
President & CEO, Buck Institute for Research on Aging · Professor, UCSF
"Verdin's research focuses on NAD+ metabolism, sirtuins, and the role of the microbiome in aging. He argues that NAD+ decline is a central driver of the aging process and that restoring it through precursors like NMN or NR can meaningfully extend healthspan."
Nir Barzilai
Director, Institute for Aging Research, Einstein College of Medicine · TAME Trial Lead
"Barzilai is the architect of the TAME trial — the first FDA-approved clinical trial to test a drug (metformin) against aging itself. He studies centenarians to understand the genetic and biological factors that allow some people to live past 100 in good health."
Matt Kaeberlein
Professor of Pathology, University of Washington · Director, Dog Aging Project
"Kaeberlein is the world's leading rapamycin researcher in the context of aging. His Dog Aging Project is testing rapamycin in companion dogs — a uniquely powered natural experiment. He argues that rapamycin is the most promising longevity intervention currently available to humans."
Brad Stanfield
General Practitioner, New Zealand · Evidence-based longevity YouTuber
"Stanfield is a practising GP who applies the same evidence standards to longevity supplements that he applies to clinical medicine. He is known for changing his recommendations when new evidence emerges — he publicly reversed his NMN recommendation after the 2023 Brenner trial showed no benefit at 600 mg."
Gabrielle Lyon
Physician · Founder, Institute for Muscle-Centric Medicine · Author, Forever Strong
"Lyon argues that skeletal muscle is the organ of longevity — and that most longevity medicine ignores it. Her muscle-centric medicine framework prioritises protein intake, resistance training, and metabolic health as the primary levers for extending healthspan, particularly in women."
Stacy Sims
Exercise Physiologist & Nutrition Scientist · Author, Roar & Next Level
"Sims is the leading voice on female-specific exercise physiology and longevity. She argues that most exercise and nutrition research has been done on men and that women — particularly peri- and post-menopausal women — need fundamentally different protocols. Her work focuses on high-intensity exercise, protein timing, and hormonal health."