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Every article in the Vitaei Journal is grounded in primary sources — randomised trials, large cohort studies, and mechanistic research. We do not publish opinion without evidence, and we cite every claim.
The press made it sound like we'd reversed aging in mice. We didn't. But we did show something narrower and more useful — that epigenetic age can be uncoupled from calendar age. A careful, paragraph-by-paragraph reading of Lu et al., Nature Aging, 2023.
What the follow-up actually showed about inflammation, lean mass and who benefited.
Most supplement protocols borrow pharmacology — and most borrow it wrong.
A gentle corrective to treating biomarker dashboards as biology itself.
We bought and assayed eight leading NMN products. Two failed identity; three failed dose.
Our editorial process, conflict-of-interest policy, and how we score evidence.
NMN, resveratrol, metformin, rapamycin, and a strict dietary pattern. We read every primary source Sinclair has cited and score each intervention on the Vitaei evidence tier system.
Attia is unusual among longevity advocates: he is skeptical of most supplements and puts exercise, sleep, and metabolic health first. We examine his framework and the evidence behind it.
Patrick's approach is rooted in biochemistry: fix micronutrient deficiencies first, then layer in heat and cold hormesis. We examine her stack and the evidence for each component.
Huberman's framework starts with light exposure and circadian biology, then layers in supplements that modulate neurotransmitter systems. We examine the evidence.
Johnson spends $2M/year and takes 111 supplements daily. We examine what the evidence supports, what is speculative, and what Blueprint has actually demonstrated.
Chronic short sleep is associated with a 12–26% increase in all-cause mortality. We examine the mechanisms, the epidemiology, and what you can actually do about it.
VO2max is the single strongest predictor of all-cause mortality in the literature. Zone 2 training is the most efficient way to build it.
Intermittent fasting has been oversold and under-nuanced. We examine the best human trials and separate what is established from what is speculative.
Grip strength is one of the strongest predictors of all-cause mortality. Muscle mass protects against metabolic disease, falls, and cancer.
Sauna use has Tier I epidemiological evidence for cardiovascular mortality reduction. Cold exposure has compelling mechanistic data but weaker human longevity evidence.
Smoking remains the largest single modifiable cause of premature death globally. We examine the dose-response data and the evidence for lifespan recovery after quitting.
For decades, moderate drinking appeared protective. The more recent Mendelian randomisation data tell a different story.
Added sugar is not just a calorie source — it is a driver of glycation, inflammation, and epigenetic aging.
Chronic psychological stress shortens telomeres, accelerates epigenetic aging, and drives inflammation. We examine the mechanisms and the evidence-grounded interventions.
Social isolation is as harmful as smoking 15 cigarettes per day, according to a meta-analysis of 148 studies. We examine the biology of loneliness and the evidence for social connection.
The 10,000-step target was invented by a Japanese pedometer company in 1965. The science says 7,000–8,000 steps per day is where the mortality curve flattens — and the benefits are dose-dependent up to that point.
Cardiorespiratory fitness, measured as VO2 max, is the strongest modifiable predictor of all-cause mortality ever identified — stronger than smoking, blood pressure, or cholesterol. Peter Attia calls it the most important number in medicine.
Centenarians have a distinct gut microbiome composition compared to younger adults. The microbiome regulates inflammation, immune function, and metabolic health — three of the most important determinants of biological age.
No dietary pattern has more RCT evidence for longevity than the Mediterranean diet. The PREDIMED trial — 7,447 participants, 5 years — showed a 30% reduction in major cardiovascular events. Here is what the evidence actually supports.
Every cell in your body runs on a 24-hour clock. When these clocks fall out of sync — through shift work, late eating, or irregular sleep — biological aging accelerates. The science of circadian medicine is one of the most important and underreported areas of longevity research.
A 2023 NIH study of 11,255 adults followed for 30 years found that adults who stay well-hydrated age more slowly, develop fewer chronic diseases, and live longer. Serum sodium — a proxy for hydration — is one of the most powerful predictors of biological age.
Vitamin D deficiency affects 40% of adults in northern latitudes and is associated with higher all-cause mortality. But the longevity benefits of sunlight extend far beyond vitamin D synthesis — nitric oxide, serotonin, and circadian entrainment all play roles.
Okinawa, Sardinia, Nicoya, Ikaria, and Loma Linda. Five populations with extraordinary longevity. The common threads are not supplements or biomarkers — they are movement, purpose, community, and plants.
Adults spend an average of 9–10 hours per day sitting. Prolonged sedentary behaviour is independently associated with higher all-cause mortality — even in people who exercise. But the relationship is more nuanced than 'sitting kills'.
Air pollution is the fourth leading risk factor for premature death globally, responsible for 6.7 million deaths per year. Indoor air quality — largely ignored — may be more important than outdoor pollution for most adults.
Every factual claim links to the original trial, cohort study, or mechanistic paper — not a press release or secondary summary.
Vitaei does not accept payment for editorial coverage. Supplement companies cannot buy a positive review or a mention in our articles.
We grade every claim by evidence type: RCT (highest), Observational, or Mechanistic — so you always know how strong the foundation is.